Abstract
BackgroundIntraclass correlation coefficients (ICCs) are used in a wide range of applications. However, most commonly used estimators for the ICC are known to be subject to bias.MethodsUsing second order Taylor series expansion, we propose a new bias-corrected estimator for one type of intraclass correlation coefficient, for the ICC that arises in the context of the balanced one-way random effects model. A simulation study is performed to assess the performance of the proposed estimator. Data have been generated under normal as well as non-normal scenarios.ResultsOur simulation results show that the new estimator has reduced bias compared to the least square estimator which is often referred to as the conventional or analytical estimator. The results also show marked bias reduction both in normal and non-normal data scenarios. In particular, our estimator outperforms the analytical estimator in a non-normal setting producing estimates that are very close to the true ICC values.ConclusionsThe proposed bias-corrected estimator for the ICC from a one-way random effects analysis of variance model appears to perform well in the scenarios we considered in this paper and can be used as a motivation to construct bias-corrected estimators for other types of ICCs that arise in more complex scenarios. It would also be interesting to investigate the bias-variance trade-off.
Highlights
Intraclass correlation coefficients (ICCs) are used in a wide range of applications
The intraclass correlation coefficient (ICC), often denoted by ρ, was first introduced by Fisher [1] to study the familial resemblance between siblings
See Donner [2] for an extensive review of inference procedures. It plays a fundamental role in studying inter-rater reliability [3,4]. It is used as a measure of heritability in classical genetic linkage studies to quantify the proportion of variance in traits of interest explained by genetic factors [5]
Summary
Intraclass correlation coefficients (ICCs) are used in a wide range of applications. most commonly used estimators for the ICC are known to be subject to bias. The intraclass correlation coefficient (ICC), often denoted by ρ, was first introduced by Fisher [1] to study the familial resemblance between siblings. Since it has obtained a wide range of applications in many areas such as psychology, epidemiology, genetics and genomics. See Donner [2] for an extensive review of inference procedures. In psychology, it plays a fundamental role in studying inter-rater reliability [3,4]. Intraclass correlation obtained from genomewide association data has recently been used to provide
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