Abstract
The most common primary brain tumors in adults are gliomas, where glioblastoma multiforme is one of the deadliest in humans. In this study, we engineered novel nanoconjugates composed of Ag-In-S/ZnS quantum dots directly stabilized by chitosan polysaccharide ligand in aqueous medium and biofunctionalized with monoclonal antibody against vascular endothelial growth factor (VEGF) receptors. These nano-immunoconjugates demonstrated bi-functional capabilities combining fluorescent emission for bioimaging and killing activity towards brain cancer cells with very promising perspectives in nanotheranostic applications.
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