Abstract
Beyond the borders: the gates and fences of neuroimmune interaction
Highlights
In most organisms the nervous, immune, and the endocrine systems have been studied as independent components
If we consider that the neuro-immune-endocrine system is just one complex regulatory system, the understanding of the interactions among the three systems can lead us to analyze many pathological states, which have usually been studied as a single disequilibrium of one of these three components, such as rheumathoid arthritis, and depression (Hernández et al, 2013)
As part of their independent study, the three systems were characterized as having highly specialized signaling molecules that constituted a fence against mutual interaction; neurotransmitters were described for neural communication, hormones for endocrine communication and cytokines and chemokines for immune signaling
Summary
In most organisms the nervous, immune, and the endocrine systems have been studied as independent components. A similar situation has been reported for neuro-immune mechanisms in which an endocrine component is disclosed, e.g., irritable bowel syndrome (Stasi et al, 2012). If we consider that the neuro-immune-endocrine system is just one complex regulatory system, the understanding of the interactions among the three systems can lead us to analyze many pathological states, which have usually been studied as a single disequilibrium of one of these three components, such as rheumathoid arthritis (del Rey et al, 2010), and depression (Hernández et al, 2013).
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