Abstract
Medicinal Research ReviewsVolume 9, Issue 2 p. 245-264 Article Beta-lactam biosynthetic genes Thomas D. Ingolia, Thomas D. Ingolia Eli Lilly and Company, Indianapolis, Indiana 46285 Thomas D. Ingolia: is a Research Scientist in the Molecular Biology Division of Lilly Research Laboratories, where he and his colleagues have studied the structure and function of beta-lactam biosynthetic genes. Dr. Ingolia's publications and patents on genes involved in penicillin and cephalosporin biosynthesis have stimulated efforts to make new antibiotics using in vitro and in vivo systems; his work has allowed the first applications of molecular biology to strain improvement of Cephalosporium acremonium and Penicillium chrysogenum. Dr. Ingolia is a member of the Society for Industrial Microbiology and the American Society for Microbiology. His training includes a Bachelor of Science Degree in Chemistry at the University of Illinois in 1974 and a Ph.D. in Biochemistry from the University of California, Berkeley in 1978. Before joining Lilly in 1981, Dr. Ingolia studied heat-shock genes in Saccharomyces cerevisiae as a postdoctoral scientist at the University of Wisconsin, Madison.Search for more papers by this authorStephen W. Queener, Stephen W. Queener Eli Lilly and Company, Indianapolis, Indiana 46285 Stephen W. Queener: is Senior Research Scientist, Department of Antibiotic Culture Development, Biochemical Division of Eli Lilly and Co., where he has worked since 1970. Dr. Queener is coauthor on patent applications for genetic transformation systems applicable to yield improvement with beta-lactam producing fungi; for isolation, sequencing, and expressing betalactam biosynthesis genes in Escherichic coli; and for yield improvement of Penicillium strains that produce mycophenolic acid. The coauthor of many articles and text chapters on the microbiology and biochemistry of beta-lactam antibiotics, he is an active member of the American Society for Microbiology. He is Secretary of the Society for Industrial Microbiology. Dr. Queener received his Ph.D. degree (1970) in biochemistry from the University of Illinois.Search for more papers by this author Thomas D. Ingolia, Thomas D. Ingolia Eli Lilly and Company, Indianapolis, Indiana 46285 Thomas D. Ingolia: is a Research Scientist in the Molecular Biology Division of Lilly Research Laboratories, where he and his colleagues have studied the structure and function of beta-lactam biosynthetic genes. Dr. Ingolia's publications and patents on genes involved in penicillin and cephalosporin biosynthesis have stimulated efforts to make new antibiotics using in vitro and in vivo systems; his work has allowed the first applications of molecular biology to strain improvement of Cephalosporium acremonium and Penicillium chrysogenum. Dr. Ingolia is a member of the Society for Industrial Microbiology and the American Society for Microbiology. His training includes a Bachelor of Science Degree in Chemistry at the University of Illinois in 1974 and a Ph.D. in Biochemistry from the University of California, Berkeley in 1978. Before joining Lilly in 1981, Dr. Ingolia studied heat-shock genes in Saccharomyces cerevisiae as a postdoctoral scientist at the University of Wisconsin, Madison.Search for more papers by this authorStephen W. Queener, Stephen W. Queener Eli Lilly and Company, Indianapolis, Indiana 46285 Stephen W. Queener: is Senior Research Scientist, Department of Antibiotic Culture Development, Biochemical Division of Eli Lilly and Co., where he has worked since 1970. Dr. Queener is coauthor on patent applications for genetic transformation systems applicable to yield improvement with beta-lactam producing fungi; for isolation, sequencing, and expressing betalactam biosynthesis genes in Escherichic coli; and for yield improvement of Penicillium strains that produce mycophenolic acid. The coauthor of many articles and text chapters on the microbiology and biochemistry of beta-lactam antibiotics, he is an active member of the American Society for Microbiology. He is Secretary of the Society for Industrial Microbiology. Dr. Queener received his Ph.D. degree (1970) in biochemistry from the University of Illinois.Search for more papers by this author First published: April/June 1989 https://doi.org/10.1002/med.2610090206Citations: 37 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume9, Issue2April/June 1989Pages 245-264 RelatedInformation
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