Abstract
In the United States alone, Heart Failure with Preserved Ejection Fraction (HFpEF) accounts for nearly five-hundred thousand admissions annually [1]. Despite medical therapy, patients with HFpEF have an estimated survival at one, three, and five years of 82%, 48%, and 33% respectively [2]. As such, reducing morbidity and mortality in these patients has become increasingly important [3,4]. Guideline recommendations suggest pharmacological strategies used in heart failure with a reduced ejection fraction (HFrEF) may benefit those with a preserved ejection fraction [4]. However, most recommendations rely heavily on expert opinion as limited data exists to direct management of HFpEF [4].
Highlights
In the United States alone, Heart Failure with Preserved Ejection Fraction (HFpEF) accounts for nearly five-hundred thousand admissions annually [1]
A recent meta-analysis including 32 randomized trials evaluated the risk for respiratory exacerbation with beta blocker use in reactive airway disease [14]
The risks described in the meta-analysis suggest that beta 1-selective agents should be used with caution in patients with reactive airway disease
Summary
Beta blockers in heart failure with preserved ejection fraction and reactive airway disease. Scalese* Assistant Clinical Professor, Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy and Adjunct Assistant Professor, Department of Internal Medicine, University of South Alabama College of Medicine, USA
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