Über die beziehung zwischen gestörtem mesenchymstoff-wechsel und veränderungen der lipidkonzentration in der gefässwand bei arterieller hypertension

Abstract

Summary 1.Arterial hypertension induces changes in the mesenchymal metabolism of rat aortic wall. This can be demonstrated by high increases of [ 35 S]sulfate incorporation into aortic sulfomucopolysaccharides. 2.Arterial hypertension is also accompanied by changes in lipid concentration of the vessel wall. This was shown for cholesterol, palmitic, oleic and linoleic acid, which all show definite increases in concentration. 3.The increase of lipid concentration in the vessel wall is almost entirely due to lipid material penetrating the wall from the blood stream, however it cannot be decided whether this is due to increased inflow or decreased outflow of lipids in the vessel wall. 4.Increased lipid concentration in the vessel wall is not an immediate consequence of arterial hypertension, since it begins developing after intensive changes in the mesenchymal metabolism and in experiments with acute hypertension of short duration even hours after blood pressure has returned to normal values.