Abstract
Inflammation and oxidative stress are closely related to cardiovascular complications and atherosclerosis, and have the potential to lead to an increase in death in patients receiving hemodialysis. Vitamin E has antioxidant and anti-inflammatory properties. We conducted a systematic review and meta-analysis to assess the effects of vitamin E supplementation on endothelial dysfunction, inflammation, and oxidative stress biomarkers in adult patients receiving hemodialysis. We searched the MEDLINE, EMBASE, Web of Science, and Cochrane Library databases and identified randomized controlled trials of adult patients receiving hemodialysis until 30 August 2021. A total of 11 trials with 491 randomized patients were included. The pooled data indicated that vitamin E supplementation significantly decreased intercellular adhesion molecule-1 [standardized mean difference (SMD): −1.35; 95% confidence interval (CI): −2.57, −0.13; p = 0.03, I2 = 89%], vascular cell adhesion molecule-1 (SMD: −1.08; 95% CI: −2.05, −0.11; p = 0.03, I2 = 81%), C-reactive protein (SMD: −0.41; 95% CI: −0.75, −0.07; p = 0.02, I2 = 64%), and malondialdehyde (SMD: −0.76; 95% CI: −1.26, −0.25; p = 0.003, I2 = 77%) levels, but not interleukin-6 levels compared to those in the control group. Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.
Highlights
Chronic inflammation and oxidative stress are strongly associated with the progression of chronic kidney disease and are common risk factors in patients with end-stage renal disease (ESRD) [1]
This review pooled the data of 11 randomized controlled clinical trial (RCT) in patients receiving hemodialysis to determine the beneficial effect of vitamin E supplementation on the reduction in biomarkers of inflammation and oxidative stress
Hemodialysis may improve survival in patients with ESRD, but increased inflammation and oxidative stress are associated with several complications, such as atherosclerosis and malnutrition, and contribute to their acceleration in these patients [14,31,32]
Summary
Chronic inflammation and oxidative stress are strongly associated with the progression of chronic kidney disease and are common risk factors in patients with end-stage renal disease (ESRD) [1]. This may induce advanced cardiovascular complications and atherosclerosis through multiple pathogenic mechanisms [2,3]. Evaluation of this state through the levels of pro-inflammatory cytokines [interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α)], and acute-phase proteins [C-reactive protein (CRP)] may help predict the risk of all-cause mortality and cardiovascular mortality in patients with chronic renal failure receiving hemodialysis [4,5]. Anti-thrombotic therapy may have a beneficial effect on thrombotic diseases in patients with CKD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
