Beneficial Effects of Coconut Oil in Treatment of Parkinson’s Disease

Abstract

Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder, characterized by depletion of dopamine resulted from the death of dopaminergic neurons in the substantia nigra. The prevalence and incidence of PD is influenced by several factors, such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures. Coconut oil (Coc) is a rich source of medium-chain triglycerides that are easily metabolized and give rise to ketones. Also, it contains antioxidants, such as vitamin E and polyphenolic compounds. It has been documented that Coc possesses significant pharmacological activities against obesity, insulin resistance, and neurodegenerative disorders, like Alzheimer’s disease and multiple sclerosis. Therefore, the purpose of this review was to describe the use of coconut oil in preventing PD and slowing its progression. Also, we tried to identify possible mechanisms by which Coc may exert its beneficial role in PD. The available literature related to Coc PD effects , in both animal models and clinical trials was screened. This review showed that Coc can be supplemented to decrease the risk of PD.