Abstract
Oxidative stress is caused by exposure to reactive oxygen intermediates. The oxidative damage of cell components such as proteins, lipids, and nucleic acids one of the important factors associated with diabetes mellitus, cancers and cardiovascular diseases. This occurs as a result of imbalance between the generations of oxygen derived radicals and the organism's antioxidant potential. The amount of oxidative damage increases as an organism ages and is postulated to be a major causal factor of senescence. To date, many studies have focused on food sources, nutrients, and components that exert antioxidant activity in worms, flies, mice, and humans. Probiotics, live microorganisms that when administered in adequate amounts provide many beneficial effects on the human health, have been attracting growing interest for their health-promoting effects, and have often been administered in fermented milk products. In particular, lactic acid bacteria (LAB) are known to conferre physiologic benefits. Many studies have indicated the antioxidative activity of LAB. Here we review that the effects of lactic acid bacteria to respond to oxidative stress, is connected to oxidative-stress related disease and aging.
Highlights
Oxidants are generated as a result of normal intracellular metabolism in mitochondria and peroxisomes, as well as from a variety of cytosolic enzyme systems, in addition, a number of external agents trigger reactive oxygen species ROS production
Probiotics, live microorganisms that when administered in adequate amounts provide many beneficial effects on the human health, have been attracting growing interest for their health-promoting effects, and have often been administered in fermented milk products
We review that the effects of lactic acid bacteria to respond to oxidative stress, is connected to oxidative-stress related disease and aging
Summary
Oxidants are generated as a result of normal intracellular metabolism in mitochondria and peroxisomes, as well as from a variety of cytosolic enzyme systems, in addition, a number of external agents trigger reactive oxygen species ROS production. The impairment caused by increased ROS is thought to result from random damage to proteins, lipids and DNA In addition to these effects, a rise in ROS levels may induce a stress signal that activates specific redox-sensitive signaling pathways. Once activated, these diverse signaling pathways may have either damaging or potentially protective functions [2]. These diverse signaling pathways may have either damaging or potentially protective functions [2] These defence systems are not effective enough to totally prevent the damage, and food supplements containing antioxidants may be used to help the human body to reduce oxidative damage [3,4,5]. We review that the effects of LAB to respond to oxidative stress, is connected to oxidative-stress related disease and aging
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