Abstract
Schizophrenia spectrum disorders are one of the most debilitating disorders as it severely impacts the day-to-day life of the individual. Therefore, during recent years, using zebrafish to model schizophrenia has become a reliable and popular choice due to the similarities in terms of genetics and brain structure to that of the human brain. Often times, the approach is to use ketamine in order to induce the positive symptoms of this disorder in zebrafish. However, this method may be lacking since it only mimics the positive symptoms, represented by delusions, hallucinations, which are not always the standard in terms of symptoms. Therefore, in the present study we have decided to approach this animal model from a different perspective by administrating methionine to replicate the negative symptoms described through increased anxiety, decreased social life and skills, and also the combination of the two substances with the purpose to get as close as possible to the way the disorder is manifested in humans. Our results support the idea that both ketamine and methionine are reliable options to induce their respective symptoms whereas the combination of the two substances does indeed lead to different behaviors compared to the individual groups.
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