Abstract
Flibanserin is a 5-HT 1A agonist that, in contrast to other 5-HT 1A receptor agonists, is capable of activating 5-HT 1A receptors in frontal cortex. Flibanserin also behaves as an antagonist at 5-HT 2A receptors. This compound has been described to be a putative fast-acting antidepressant owing to these properties. In the present study, the effect of flibanserin was investigated in several behavioral paradigms different from animal models of depression. Intraperitoneal flibanserin, at doses of 4–8 mg/kg, antagonized d-amphetamine– and (+)SKF-10047– induced hypermotility in mice and rats. At doses of 8–16 mg/kg, flibanserin exerted anxiolytic-like effects in the light/dark exploratory test and stress-induced hyperthermia in mice, and antagonized d-amphetamine– and apomorphine-induced stereotypy in rats. At the dose of 16 mg/kg, flibanserin reduced spontaneous motor activity in rats. At the dose of 32 mg/kg, flibanserin did not exert any clear effect on spontaneous motor activity in mice, or on the elevated plus-maze and the water maze in rats.
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