Behavioral deficits in monosodium glutamate rats: Specific changes in the structure of feeding behavior

Abstract

We studied the feeding rhythms and feeding patterns of adult Long-Evans rats treated with monosodium glutamate (MSG) in their early post-natal period. This treatment is known to induce neuronal degeneration in the arcuate nucleus (ARC), a major hypothalamic site implicated in the regulation of feeding. Neonatal rats were treated intraperitoneally with MSG or saline (controls) alone on the first days of life. At age of 6 months, male control and male MSG rats were placed in our automatic feeding system, and the structure of feeding behavior and diurnal feeding rhythms were analysed. On a 24 hours basis, MSG rats ate less than control rats (− 24 %). This hypophagia resulted from a mild diurnal hyperphagia (+ 6 %) and a pronounced nocturnal hypophagia (− 34 %). This hypophagia was the main consequence of a decrease of meal size in MSG rats (− 37 %) and was associated with an increase in meal duration (+ 52 %). It was also associated with a total disappearence of the two feeding peaks that normally occur at light and dark onset in the rat (− 90 % 2 h after dark onset and − 49 % 2 h before light onset). These results indicate that neonatal treatment with MSG induces important changes in feeding patterns and feeding rhythms in the adulthood. These changes might be related to the disappearance of neurotransmitters located in the arcuate nucleus.