Abstract
We investigated the effects of high-cholesterol diet on lipid metabolism in MSG-rat in the following four groups.(1) MSG (-), Normal diet.(2) MSG (-), High-cholesterol diet.(3) MSG (+), Normal diet.(4) MSG (+), High-cholesterol diet.In lipoprotein profil, VLDL-triglyceride was increased in MSG (+) groups, (3) and (4). VLDL-cholesterol were increased in high-cholesterol diet administered groups, (2) and (4). In the liver, content of cholesterol ester, free cholesterol and triglyceride were increased in high-cholesterol diet groups, (2) and (4), compared with those in normal diet groups, (1) and (3), respectively. Triglyceride content was higher in MSG (+) groups, (3) and (4), than that in MSG (-) groups, (1) and (2), respectively. Free fatty acid uptake into cholesterol ester in liver was higher in (3) than that in (1). It was increased in control rats (2), but decreased in MSG rats (4), by administration of high-cholesterol diet. Free fatty acid uptake into triglyceride in liver was increased by high-cholesterol diet administration in both MSG (4) and control rats (2). Acid cholesterol esterase activity in aorta was also increased by high-cholesterol diet administration in MSG (4) rats in as same degree as in control rats (2).
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