Abstract
Samples of swine blood were evaluated immediately following in vivo or in vitro exposure to 14 MeV neutrons. Leukocyte cultures established from these samples were appraised after 0, 24, 48, 72, and 96 hours in culture on the basis of changes in cell type, viability, DNA synthesis and mitotic rates, polyploid rates, and nuclear volume distributions. Most of the criteria evaluated did not show major differences which could be attributed to a differential response of the cells to irradiation under the two conditions. The initial neutrophil content, the proportion of lymphocytes in cultures at 72 hours, and the rate of polyploid expression at this same time were significantly related to the dose level administered. The extent of nuclear volume increase by cells in response to PHA stimulation was suppressed by both irradiation conditions but to a greater extent by in vivo exposure.
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