Abstract
Hemolytic behavior of rabbit and human erythrocytes in water-glycerin and water-propylene glycol solutions was studied at 25 and 37°, and the effect of various added substances to these systems was investigated. Human <i>i</i> values obtained for sodium chloride in aqueous glycerin or propylene glycol solutions at 37° were slightly greater than the corresponding <i>i</i> values at 25°. Increase in temperature from 25 to 37° decreased the concentrations of propylene glycol in 0.9 per cent saline solution needed to cause hemolysis of erythrocytes. Mono-monovalent salts, sugars and sugar alcohols, magnesium chloride, and sulfate and sodium succinate afforded essentially the same degree of protection as sodium chloride against hemolysis by propylene glycol. Isotonic concentrations of sodium or potassium sulfate, potassium sodium or disodium tartrate, or trisodium citrate afforded greater protection to erythrocytes than 0.9 per cent sodium chloride. The order in which the anions of the above salts appeared to protect human erythrocytes against propylene glycol hemolysis is citrate>tartrate>gluconate>sulfate; for rabbit erythrocytes the order is sulfate, tartrate>citrate. Much lower concentrations of propylene glycol were required to hemolyze erythrocytes in solutions containing isotonic concentrations of calcium chloride.
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