Abstract
The degree of hemolysis of rabbit and human erythrocytes in solutions of a series of monohydric and polyhydric alcohols was investigated. When possible, these data were used to calculate van't Hoff i values. The monohydric and polyhydric alcohols which had a molecular weight less than that of erythritol caused complete hemolysis in concentrations calculated to be isosmotic. Certain concentrations of the monohydric alcohols caused hemolysis even in the presence of 0.6 per cent (0.1 M ) sodium chloride. The low molecular weight diols and triol investigated did not cause hemolsis in the presence of 0.6 per cent sodium chloride. The olyhydric alcohols of higher molecular weight prevented hemolysis. It appeared that the phenomena occurring at the erythrocyte membrane in the case of the alcohols might be influenced by molecular weight and the number of hydroxyl groups present; the ratio of hydroxyl groups to the number of carbon atoms in the molecule might be important.
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