Abstract
The transcription factor Bcl6 is essential for development and differentiation of T follicular helper (Tfh) cells in draining lymph nodes (dLNs), which are pivotal for antigen-specific IgE antibody production. During immune responses, a subset of Foxp3+ regulatory T cells that express Bcl6, namely T follicular regulatory T (Tfr) cells, is also generated in dLNs. Our knowledge is limited regarding the roles of these Tfr cells in allergic immune responses.
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