Abstract
Publisher Summary Gross chemical reactivity of diol epoxides—a fundamental assumption of the bay-region theory—helps in the understanding of hydrocarbon-induced carcinogenicity. However, several other structural and metabolic factors must be taken into account for specific hydrocarbons. Thus, regiospecificity of the cytochrome P-450 system must be such that a significant amount of the active dihydrodiol can be formed with the aid of epoxide hydrase. The conformation and enantiomeric makeup of this dihydrodiol are also important. The extent of formation and diastereomer as well as enantiomer composition of the diol epoxides formed from the dihydrodiol by the cytochrome P-450 system are dependent upon these factors. Conformation of diol epoxides also determines biological activity. This chapter discusses several metabolic factors that play determining roles in establishing relative carcinogenicity for the polycyclic hydrocarbons; however, other factors such as rates of repair of chemical damage to the cell and differences in immunocompetence may prove to be important.
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