Base-controlled reaction of α,β-unsaturated trifluoromethyl ketone and dialkyl phosphite

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Base-controlled selective reactions of α,β-unsaturated trifluoromethyl ketones with dialkyl phosphites were achieved. In the presence of DABCO, the Pudovik reaction took place readily to give the corresponding α-hydroxy phosphonates in high yields under mild conditions. While using DBU as base, the Phospha-Brook rearrangement of α-hydroxy phosphonates formed in the reaction occurred to afford phosphates as final products.