Abstract
An alternative green protocol and step economy for the synthesis of quinazoline has been developed. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to ortho-aminoaryl NH ketimine species. The subsequent base catalysed NC bond formation with various isothiocyanates afforded quinazoline scaffolds in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
