Abstract
Basaloid squamous cell carcinoma (BSCC) is a rare aggressive variant of squamous cell carcinoma (SCC). We report a case of a 42-year-old male patient, a smoker and alcoholic, presenting a painless erythroleukoplakia lesion in the floor of the mouth, measuring approximately 2.5 cm in diameter with 5 months of evolution. There were bilateral palpable submandibular lymph nodes. The presumptive diagnosis was SCC, and an incisional biopsy was carried out. Pathologic analysis revealed proliferation of nests, islands, and trabeculae of basaloid cells with hyperchromatic nuclei and scarce cytoplasm. An atypical squamous component was evident in some regions of the specimen. Immunohistochemical analysis revealed intense positivity for CK14 and P16 and negativity for CK7. The diagnosis was BSCC. The patient was referred to a public head and neck oncology service for definitive surgical treatment and radiotherapy. A discussion on the clinical, histopathologic, immunohistochemical, and therapeutic aspects of BSCC will be provided. Basaloid squamous cell carcinoma (BSCC) is a rare aggressive variant of squamous cell carcinoma (SCC). We report a case of a 42-year-old male patient, a smoker and alcoholic, presenting a painless erythroleukoplakia lesion in the floor of the mouth, measuring approximately 2.5 cm in diameter with 5 months of evolution. There were bilateral palpable submandibular lymph nodes. The presumptive diagnosis was SCC, and an incisional biopsy was carried out. Pathologic analysis revealed proliferation of nests, islands, and trabeculae of basaloid cells with hyperchromatic nuclei and scarce cytoplasm. An atypical squamous component was evident in some regions of the specimen. Immunohistochemical analysis revealed intense positivity for CK14 and P16 and negativity for CK7. The diagnosis was BSCC. The patient was referred to a public head and neck oncology service for definitive surgical treatment and radiotherapy. A discussion on the clinical, histopathologic, immunohistochemical, and therapeutic aspects of BSCC will be provided.
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