Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis.

Sukmawati Tansil Tan,Ricky Dosan,Peter J Heenan,Mahmud Ghaznawie

doi:10.1155/2018/3098940

Sukmawati Tansil Tan, Ricky Dosan + Show 2 more

Open Access

https://doi.org/10.1155/2018/3098940

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Abstract

Background BCC is currently the most common type of skin cancer in humans. Although having a low-grade malignancy and metastatic potential, BCC is locally aggressive and destructive. Despite numerous studies, the origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. Objectives This study aims to evaluate whether BCC arises from the follicular or interfollicular layer by using immunohistochemical staining. Methods Twenty-three specimens of superficial and nodular BCC at its very early stage were examined. The samples were immunohistochemically stained using BerEP4 antibody. The stained specimens were then examined and scored by 2 independent observers. Results BerEP4 was found to be strongly positive in all BCC lesions, including a very early lesions budding off the basal layer of the epidermis. Conclusion This study confirmed that the origin site of BCC is basal layer of epidermis. This finding suggests that BCC arises from the interfollicular epidermis.

Highlights

Basal cell carcinoma ORS (BCC) is one of the most frequently occurring cancers and the most common skin cancers in humans [1]
In this study 26.09% BCC lesions were located on face (n=6); others were located on ankle (8.7%, n=2), back (8.7%, n=2), lower leg (8.7%, n=2), shoulder (8.7%, n=2), upper leg (4.35%, n=1), and chest (4.35%, n=1)
BerEP4 staining was done to confirm that the sections were of early stage BCCs and the exact location of these early lesions

Summary

Introduction

BCC is one of the most frequently occurring cancers and the most common skin cancers in humans [1]. An estimated 900.000 to 1 million are diagnosed in America, 550.000 men to 350.000 women, with around a 2:1 ratio. This prevalence is projected to increase twice in every 25 years, with the ratio becoming 3:2 [4]. The origin of BCC, whether arising from the follicular or interfollicular layer, remains controversial. This study aims to evaluate whether BCC arises from the follicular or interfollicular layer by using immunohistochemical staining. This study confirmed that the origin site of BCC is basal layer of epidermis. This finding suggests that BCC arises from the interfollicular epidermis

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Discussion

Conclusion