Barrier-protective properties of pterostilbene against LPS-induced sepsis

Abstract

Background: Sepsis is a major clinical problem and the leading cause of death in patients in intensive care units worldwide. Objective: The present study aimed to explore whether pterostilbene (PTS) could protect mice against experimental endotoxemia. Methodology: Forty-eight mice were randomly divided into 4 groups and challenged with LPS. Mouse mortality was observed twice daily for 7 days and survival rates were reported. Mice were randomly treated with pterostilbene or vehicle intraperitoneally (i.p.). One hour later, the animals were exposed to LPS (20 mg/kg). Cytokine responses were then assessed in serum isolated from blood collected after LPS administration to the mice. Results: The results showed that pterostilbene significantly reduced mouse body weight loss and attenuated inflammatory responses by inhibiting TNF-α, IL-6 and IL-1β production in mice exposed to LPS. Conclusion: This study highlights the role of pterostilbene in the pathogenesis of LPS-induced sepsis and its potential in the treatment of patients with sepsis.