Abstract

Barrier Integrity Damage-Elicited Allergic Response (BIDEAR) Syndrome: A Proper Entity?

Highlights

  • The role of the accidental trigger is considered as part of a proper pathological entity, as long as the barrier damage in concert with the pro-allergic immune response was a key factor in the eliciting of the allergic carrier

  • We attempted to integrate the event of traumarelated barrier destruction as a constitutive part of a proper diagnostic entity when allergic sensitization is elicited as a result of the mentioned accident, suggesting the term: “Barrier Integrity Damage-Elicited Allergic Response (BIDEAR) Syndrome”

  • The damaging of the epithelial barrier and Th2 polarization during atopic allergy show modulation of dendritic cell (DC) function, and an innate immune response to allergens with toll-like receptor 9- and toll-like receptor 4-stimulating conjugates [4]. This is possible because the DCs placement at the interface between body surfaces and the environment is ideal for allergen capture, and thereafter, for the inducing of tolerance or initiating and persisting of the immuno-inflammatory response [6, 7]

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Summary

Introduction

The disturbed permeability barrier plays an important role in numerous inflammatory diseases [1]. This work shows cases of allergic sensitization that are elicited by mechanical trauma, proposing to comprise this decisive event in the nomenclature of pathologic entity

Cases Presentation
Discussion

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