Abstract
Non-pharmaceutical interventions have been implemented intermittently for more than a year in most countries of the world to mitigate the COVID-19 epidemic. In France, while the vaccination campaign is progressing, the French government has decided to remove many public health restrictions such as business closure, lockdowns, and curfews. Nonetheless, social distancing, mask wearing, and hand washing (also called barrier gestures) are still recommended. We utilize an age-structured compartmental SEIR model that takes into account the SARS-CoV-2 waning immunity, vaccination, and increased transmissibility from variants of concern to estimate if barrier gestures can be relaxed without causing a resurgence of severe infections. This model assumes that the susceptibility to infection is a function of immunity status, which depends on initial infection severity and vaccination status. It is calibrated on confirmed COVID-19 cases from the French surveillance database, and accounts for changes in contact behaviors due to the implementation of nation-wide public health policies. We study the partial and full relaxation of barrier gestures occurring from August to December 2021 under various immunity duration assumptions. Maintaining the application of barrier gestures appears essential to avoid a resurgence of severe infections that would exceed French health care capacities, while surmounting vaccine hesitancy represents the key to consider their relaxation. Immunity duration assumptions significantly influence the short-term dynamic of the epidemic, which should be considered for further modelling.
Highlights
Causing more than 200 million infections and at least 4.4 million deaths worldwide, the COVID-19 epidemic is a global health, economic, and social crisis
Assuming that immunity completely wanes over 3 years, years, we find that the intensive care units’ (ICU) hospitalization peak is, on average, 86.1% higher than the same we find that the hospitalization peak is, on average, 86.1%
We used an age-structured compartmental model of COVID-19 that takes into ac4
Summary
Causing more than 200 million infections and at least 4.4 million deaths worldwide, the COVID-19 epidemic is a global health, economic, and social crisis. The causative agent, SARS-CoV-2, emerged in China’s Hubei province in December 2019. Various non-pharmaceutical measures, in particular lockdown and social distancing, have been implemented around the world to effectively control the spread of the virus [1,2]. All of these measures have negative economic and social consequences, as well as repercussions on the mental health of populations. As of 30 August 2021, more than 5 billion doses of the vaccine have been administered worldwide [3]
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