Abstract
Neurons communicate primarily via the release of chemical neurotransmitters from presynaptic nerve terminals and their detection post-synaptically. Thus, the process of synaptic vesicle exocytosis is at the heart of neuronal function and cognition. Intriguingly, the proteins that play the key role in the fusion of vesicles with membranes, the SNARE proteins, are IDPs, and a number of the additional factors that regulate neuronal SNARE function are also intrinsically disordered, including the proteins alpha-synuclein and complexin. Our work has helped to establish the mechanisms by which disorder-to-order transitions in both complexin and alpha-synuclein contribute to the functional aspects of these proteins, and in the case of alpha-synuclein, to their role in neurodegenerative disease as well. Recent progress in these areas will be described.
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