Bacteriological profile and sensitivity pattern of microorganisms causing Urinary Tract Infection at a tertiary care center in eastern Uttar Pradesh

Ruchi Mishra,Amresh Kumar Singh,Jayesh Pandey,Kusum Jasuja

doi:10.7439/ijbar.v7i6.3366

Abstract

Introduction: Urinary tract infection (UTI) is one of the most common infections worldwide, and the pattern of antimicrobial susceptibility varies widely in different regions depending on the antibiotic policies. Aim: To know the bacteriological profile of UTIs and the antibiogram of uropathogens in eastern Uttar Pradesh. Material and Methods: This study was prospective and conducted at tertiary care center in one year study duration (2015). All the patients clinically suspected of having UTI were enrolled, their culture and sensitivity was performed as per standard protocol, irrespective of age, sex, indoor/outdoor and associated illnesses. Results: In a total of 2217 patients, 967 (43.61 %) were positive for uropathogen by culture, and positivity in female was high (46.48%) as compared to male (38.46%). Escherichia coli was the most common 346 (35.80 %) uropathogen followed by Klebsiella pneumoniae 183 (18.92%) and Enterococcus species 125 (12.92%). Gram negative isolates were most sensitive to imipenem (92%), ceftazidime-clavulanate (71%), piperacillin-tazobactam (68%), amikacin (60%), followed by nitrofurantoin (56%) as compared with fluoroquinolones. Gram positive isolates were most sensitive to vancomycin (91%) followed by linezolid (80%) and amoxycillin-clavulanic acid (45 %). Conclusion : UTI is a very common problem and rate of antibiotic resistance is relatively high. Imipenem, ceftazidime-clavulanic acid, piperacillin-tazobactam, amikacin, vancomycin and linezolid, were found sensitive against isolated uropathogens.

Highlights

Urinary tract infection (UTI) is one of the most common infections worldwide and the pattern of antimicrobial susceptibility varies widely in different geographical regions depending on the antibiotic policies
The diagnosis of UTI is primarily based on signs and symptoms rather than isolated laboratory findings; importantly, bacteriuria is not a disease the collection and interpretation of urine cultures should be based on the clinical scenario.[3]
Male children (

Summary

Introduction

Urinary tract infection (UTI) is one of the most common infections worldwide and the pattern of antimicrobial susceptibility varies widely in different geographical regions depending on the antibiotic policies. Urinary tract infections (UTIs) are the most common bacterial infection encountered in tertiary care settings.[1]. The diagnosis of UTI is primarily based on signs and symptoms rather than isolated laboratory findings; importantly, bacteriuria is not a disease the collection and interpretation of urine cultures should be based on the clinical scenario.[3] Generally, women with acute uncomplicated cystitis culture are not recommended. For individuals with acute pyelonephritis or complicated UTI it is important to obtain a urine culture in order to find the appropriate antimicrobial regimen, prior to start empiric therapy.[4] Antimicrobial prescription should be prudent and rational. The choice of antimicrobial agents should be preferably based on the patient’s allergy history, antibiogram pattern, availability, cost and compliance.[5]

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Conclusion