Abstract
Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. σ Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Recently, engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria.
Highlights
The present review summarizes the recent advances in σ factor based engineering or synthetic design
We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria
The transcriptional network of bacteria contains an extensive hierarchy of regulators with the RNA polymerase (RNAP) and σ factors toward the top and other transcription factors (TF) toward the bottom that control the regulatory network of gene transcription (Ishihama, 2010)
Summary
Bacterial sigma factors as targets for engineered or synthetic transcriptional control. Reviewed by: Baojun Wang, University of Edinburgh, UK Patrik R. Imperial College London, UK Takashi Osanai, RIKEN Center for Sustainable Resource Sciences, Japan. Sigma (σ) factors are the predominant constituents of transcription regulation in bacteria. Σ Factors recruit the core RNA polymerase to recognize promoters with specific DNA sequences. Engineering of transcriptional regulators has become a significant tool for strain engineering. The present review summarizes the recent advances in σ factor based engineering or synthetic design. The manipulation of σ factors presents insights into the bacterial stress tolerance and metabolite productivity. We envision more synthetic design based on σ factors that can be used to tune the regulatory network of bacteria
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