Abstract
Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.
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