Abstract
Bacterial cellulose (BC) is a nanofibrous biocompatible scaffold used in bone tissue engineering. Graphene oxide/hydroxyapatite (GOHA) composite supports the adhesion of osteoblast cells with good viability. In the present study, GOHA was prepared by the wet chemical precipitation method, and BC obtained from Acetobacter aceti was added to the aqueous suspension of GOHA to prepare GOHABC. The scanning electron microscopic image of GOHABC showed uniform adsorption of GOHA on the surface of BC. The osteoinductive potential of the GOHABC scaffold was analyzed by alkaline phosphatase (ALP) activity assay using MG-63 cells, and its biocompatibility nature was studied by using both MG-63 and NIH-3T3 cells. The ALP activity and biocompatibility studies showed that GOHABC is a potential osteoinductive material in vitro and may be tried in the future for in vivo studies.
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