Back Cover: Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation

Abstract

Mol. Nutr. Food Res. 2022, 66, 202100210 DOI: 10.1002/mnfr.202100210 The subject of this picture is a white mouse lying in a peanut plant. The background is an electroencephalogram, which represents the sleep state of the mouse. The chemical structure formula of 4',7-di-O-methylnaringenin and 2'-O-methylisoliquiritigenin, may be the main active components in peanut stem and leaf extract, are located at the top. The first circle in the right represents the electroencephalogram and electromyogram of the mouse administrated with peanut stem and leaf extract, the second circle represents the synapses in cortical neurons, the third circle represents the voltage-gated sodium channel and the voltage-gated potassium channel on cortical neurons, the fourth circle represents the inhibition of action potentials by these two flavonoids on cortical neurons, and the fifth circle shows the interaction between these two flavonoids with Nav1.2 separately. This picture shows the sleep-promoting properties of peanut stem and leaf with the potential mechanism of the inhibition on neuronal excitability. This is reported by Chen Zhang, Qiang Wang, and co-workers in article number 2100210.