Abstract
European Journal of ImmunologyVolume 47, Issue 3 Back CoverFree Access Back Cover: Eur. J. Immunol. 3'17 First published: 13 March 2017 https://doi.org/10.1002/eji.201770038AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Our back cover features the typical perivascular loss of immunoreactivity for the water channel protein AQP4 in astrocytes as seen in neuromyelitis optica (NMO). The image is taken from Vogel et al. (pp. 458–469), where the authors identify AQP4(201-220) as major I-Ab restricted T-cell epitope of full length AQP4. In wild type mice, both the endogenous T-cell and the B-cell repertoires are purged of AQP4 reactive clones due to deletional tolerance. In transfer experiments, AQP4(201-220) specific T cells alone induce clinical signs of encephalomyelitis. However, only the simultaneous presence of AQP4 specific T cells and anti-AQP4 antibodies results in NMO-like lesions in the brain. The image has been digitally altered for the cover. Volume47, Issue3March 2017 RelatedInformation
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