Abstract
Basic Science Liver
Highlights
Innate lymphoid cells (ILCs) are a recently described immune cell population that has been shown to mirror the phenotype and function of T cells without the requirement for antigen specificity
A drop in pressure is consistent with the establishment of collateral circulation in this model. quantitative polymerase chain reaction (qPCR) analysis showed jejunal angiotensin II type 1 receptor (AT1R) expression was downregulated (P < 0.005) by more than sixfold from Day 1 to about threefold at Day 14 after partial portal vein ligation (PPVL), whereas angiotensin converting enzyme 2 (ACE2) expression tended to be increased
We found that in this vasculature, both angiotensin II type 2 receptor (AT2R) (P < 0.05) and ACE2 (P < 0.0005) were downregulated in PPVL rats compared with sham-operated controls
Summary
Innate lymphoid cells (ILCs) are a recently described immune cell population that has been shown to mirror the phenotype and function of T cells without the requirement for antigen specificity. Conclusion: hAECs and hAEC-CM reduce liver fibrosis and macrophage infiltration in a fast-food dietinduced murine model of non-alcoholic fatty liver disease through reduced stellate cell activation, reduced TGF-β signaling, increased matrix metalloproteinase expression, and decreased macrophage numbers. ACE2 therapy significantly (P < 0.05) downregulated pro-inflammatory IL-6 and MCP-1 gene expressions in diabetic mice compared with the control vector-treated mice These changes were associated with a significant (P < 0.05) reduction in the activation of hepatic stellate cells, as reflected by reduced αSMA expression, leading to a significant reduction in the expression of profibrotic cytokines, TGF-β1 and CTGF, and matrix component collagen 1. Profound reduction in proinflammatory and profibrotic cytokine, and matrix gene expression in ACE2-treated mice has led to a significant reduction (P < 0.05) in hepatic fibrosis in diabetic NAFLD mice compared with that in the control vector-injected mice.
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