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Abstract
Abstract Commensal bacteria are being studied for their probiotic, or beneficial effects in a number of diseases. Probiotics have been proposed as a therapy for food allergy but the mechanism and efficacy of how probiotics may be preventing disease are not understood. We previously showed that we can limit diarrheal disease caused by the enteric pathogen Citrobacter rodentium using the probiotic Bacillus subtilis. In addition we isolated the protective molecule, exopolysaccharide (EPS) and shown EPS alone is sufficient for protection of disease. Food allergy and the anaphylactic response following allergen exposure are mediated by mast cell degranulation. We have evidence that EPS can suppress mast cell-dependent degranulation and anaphylaxis. Therefore, we hypothesize that EPS protects against anaphylaxis through the suppression of mast cell activation. Identifying the mechanism by which EPS prevents anaphylaxis will provide the first safe and effective therapeutic use of a probiotic for the treatment of food allergy.
Published Version
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