Abstract
Abstract The incidence of allergies is on the rise, and to prevent or treat allergic diseases, we need a means of inhibiting immune pathways leading to allergic responses. Reduced exposure to microbes, increased use of antibiotics and changes in diet all lead to an increase in allergies. The consequences of these changes in lifestyle include an alteration of intestinal bacteria that are important for development of the immune system. Our work seeks to utilize the beneficial effects of gut microbiota to manipulate allergic responses. A key cell responsible for the symptoms of allergies is the mast cell. We are using the probiotic bacterium Bacillus subtilis which produces an exopolysaccharide (EPS) with anti-inflammatory activity. We found that EPS treatment alone was unable to alter mast cell degranulation following IgE-mediated activation, however treatment with peritoneal cells from EPS-injected mice prevented mast cell degranulation. We hypothesize that EPS induces a suppressive cell in the peritoneal cavity that leads to the suppression of mast cell activation and could be used to suppress the immune response against common food or environmental factors.
Published Version
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