Abstract
The four members of the family Herpes viridae that most frequently infect humans are herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV). The prevalence of infection with these viruses ranges from between 20% and 40% (HSV) to virtually 100% (VZV, CMV, EBV). These four enveloped DNA viruses characteristically cause latent or persistent infections, or both, which may last for the lifetime of the host. 1 Latent virus may be found in the nervous system (HSV and VZV), lymphoid system (EBV and CMV) and perhaps other tissues including skin (CMV). 1 In the setting of HIV disease and its associated immune suppression, previously asymptomatic or mild infections often become much more severe. This article discusses the cutaneous lesions caused by HSV, VZV and CMV. The role of EBV is not discussed here.
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