Abstract
B type natriuretic peptide (BNP) and its precursor, the inactive form of NT-pro-BNP, are currently the most studied laboratory parameters in the heart disease spectrum. The assessment of their blood concentrations provides invaluable information on the likelihood, severity and prognosis of the disease. The present review aims to describe the biological determinants, the factors that influence these peptide concentrations, the suggested cutoff values for the diagnosis of heart failure and the use of this biomarker in the assessment of cardiac function.
Highlights
The natriuretic peptide family consists of atrial natriuretic factor (ANF), brain natriuretic peptide, called type B (BNP), and C-type natriuretic peptide (CNP)
The messenger ribonucleic acid of the atrial natriuretic factor has been found in many tissues, it is abundant in the cardiac atria
In response to distension of the atrial tissue, there is an increase in ANF and B type natriuretic peptide (BNP) plasma concentrations, which antagonize the effects of angiotensin II in vascular tone, aldosterone secretion, sodium reabsorption and vascular cell growth
Summary
Adriana Polachini do Valle; Paulo José Fortes Villas Boas; Edison Iglesias de Oliveira Vidal; Fernanda Bono Fukushima abstract. B type natriuretic peptide (BNP) and its precursor, the inactive form of NT-pro-BNP, are currently the most studied laboratory parameters in the heart disease spectrum. The assessment of their blood concentrations provides invaluable information on the likelihood, severity and prognosis of the disease. The present review aims to describe the biological determinants, the factors that influence these peptide concentrations, the suggested cutoff values for the diagnosis of heart failure and the use of this biomarker in the assessment of cardiac function
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