Abstract
Abstract Background Using 219 samples collected from volunteer employees of our lab, obtained in different times after Sars-CoV-2 Pfizer-BioNTech vaccination, we compared two semi-quantitative tests: Methods Abbott's AdviseDx SARS-CoV-2 IgG II and Beckman Coulter’s Access SARS-CoV-2 IgG II assay. Both assays detect IgG antibodies to the receptor binding domain of the S1 subunit of the spike protein of SARS-CoV-2 in serum and plasma of tested individuals. For the Beckman test, AMR is from 0 to 450 AU/ml with cut off for positive test 10 AU/ml; for the Abbott test, AMR is from 0 to 25000 AU/ml with cut off for positive test 100 AU/ml. Results Using a fitted regression line, it appears that the best correlation between these two tests was found in the lower value range, below 25AU/ml for Beckman test and 4000 AU/ml for Abbott test (R-squared value of 0.842 and y=87.165x). For higher antibody levels, the result distribution resembles a binary pattern, which we find very interesting. We will discuss possible explanations of this finding. Conclusions
Published Version
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