Abstract
Azacoccones A–E (1–5), five new aza-epicoccone derivatives, were isolated from the culture of Aspergillus flavipes. Their structures were determined by extensive NMR spectroscopic analyses and the absolute configuration of 5 was determined by electronic circular dichroism (ECD) calculation. Compounds 1–5 are proposed to be generated via a Pictet-Spengler reaction-based biosynthetic route starting from the precursor flavipin. Pictet–Spengler reaction is rarely found in the fungal kingdom, which indicated the distinctive nature of 1–5. Compounds 3 and 5 exhibit significant free radical scavenging activities with IC50 values of 4.0 and 2.4μg/mL, respectively, which are better than the positive control trolox (4.55μg/mL).
Published Version
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