Abstract
Publisher Summary This chapter discusses the aza analogs of pyrimidine and purine bases of nucleic acids. The analogs of pyrimidine and purine bases can be derived by purely formal structural modifications or, more rationally, from the results of biochemical investigation. An important group of antimetabolites are the aza analogs of pyrimidine and purine bases which are theoretically derived by a replacement of the methine group of a pyrimidine or purine nucleus with a nitrogen atom. The replacement of the methine group with a nitrogen atom can be effected in position 5 or 6 of the pyrimidine base. This result in analogs described as “5-aza” and “6-aza.” The chemistry of the aza analogs of pyrimidine bases represents a part of the chemistry of the corresponding heterocyclic (triazine) group. The chapter reviews the studies dealing with the biological activity of aza analogs. The nomenclature of aza analogs is discussed in the chapter. The UV spectra are measured practically for all the numerous derivatives.
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