Abstract
Axonal signals are key players in central nervous system myelination. During development, the onset of myelination depends on a balance between positive and negative axonal signals. Among negative signals are inhibitory adhesion molecules that need to be removed from the cell surface for the myelination process to proceed. Positive signals necessary to initiate myelination consist of both interactions with specific adhesion molecules and electrical activity-induced release of promyelinating factors. In multiple sclerosis, demyelination induces major modifications of axonal surface components. The disruption of these factors might participate to the failure of the myelin repair process.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.