Abstract
Axonal messenger RNA (mRNA) transport serves to spatially restrict protein synthesis to the axon and growth cone. The molecular mechanism for axonal mRNA transport involves the recognition of zipcodes by RNA-binding proteins, assembly into RNA granules, and transport along the microtubules and actin filaments in the axon and growth cone. Local translation of mRNAs provides developing growth cones with the capacity to autonomously regulate their structure and function during axonal growth and navigation. In mature axons, local protein synthesis is stimulated on injury and might facilitate the process of regeneration.
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