Abstract
Awakening p53 in senescent cells using nutlin-3
Highlights
The p53 tumor suppressor protein is arguably the most important guardian of the mammalian genome. p53 promotes longevity by reducing somatic mutations or the survival and proliferation of mutant cells
Nutlins are cis-imidazoline analogs, which inhibit the interaction between MDM2 and p53, and were discovered by screening a chemical library done by Vassilev and colleagues [4]
There is no direct link between cellular senescence and aging, a correlation does exist, as the number of senescent cells increases in mammals as they age [5]
Summary
The p53 tumor suppressor protein is arguably the most important guardian of the mammalian genome. p53 promotes longevity by reducing somatic mutations or the survival and proliferation of mutant cells. Almost all human cancers contain impairments in the p53 signaling pathway [3]. Intense focus on understanding p53 regulation at the molecular level has led to interest in isolating and developing smallmolecule targets of p53 activity to treat various forms of cancer. Nutlins prevent p53-MDM2 interaction, and induce expression of p53-regulated genes, which exhibit potent anti-proliferative activities (Figure 1A).
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call