Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes.

Youn Hee Nam,Tong Ho Kang,Rodrigo Castañeda,Jung Suk Lee,Do Hoon Kim,Yu Hwa Park,Kye Wan Lee,Kwang Won Jeong,Se-Young Choung,Bin Na Hong,In Seok Moon,Min Seon Park,Wanlapa Nuankaew,Yun Hee Kim,Seung Hyun Kim,Thu Nguyen Minh Pham,Isabel Rodriguez,Seo Yeon Jeong,Seo Yule Jeong

doi:10.3390/nu11010113

Abstract

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

Highlights

Sensorineural hearing loss (SNHL) is a major disease worldwide that is categorized as age-related, noise-induced or idiopathic
DKB122, our results show that DKB122 protects House Ear Institute-Organ of Corti 1 (HEI-OC1) cells from the altered amino acid biosynthesis death
Study,wewe focused on avocado as a of source of fatty and severalcompounds bioactive with pharmacological potential pathology, prevention is still the main goal attenuate compounds with pharmacological potential [7]

Summary

Introduction

Sensorineural hearing loss (SNHL) is a major disease worldwide that is categorized as age-related, noise-induced or idiopathic. SNHL accounts for approximately 90% of reported hearing loss [1,2,3,4,5]. Over 466 million people are living with disabling hearing loss worldwide, and this number is projected to increase to 933 million by 2050 (World Health Organization, 2018). Prevention or treatment of hearing loss has not been widely studied. We have been searching for foods with potential to treat SNHL. We identified avocado oil as a promising functional food

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Methods

Conclusion