Abstract
BackgroundDespite advanced treatments could inhibit progression of colorectal carcinoma (CRC), the recurrence and metastasis remain challenging issues. Accumulating evidences implicated that AVL9 played a vital role in human cancers, but it’s biological function and mechanism in CRC remain unclear.AimTo investigate the biological role and mechanism of AVL9 in colorectal carcinoma.ResultsAVL9 expression was significantly upregulated in tumor tissues than that in matched normal tissues both at mRNA and protein levels. High expression of AVL9 was closely correlated with M status, stages and poor prognosis of colorectal carcinoma (CRC) patients. Functionally, AVL9 overexpression promoted cell migration rather than cell proliferation in vitro, whereas AVL9 knockdown exhibited the contrary results. Mechanistically, AVL9 regulated EGFR expression, and knockdown of EGFR restrained AVL9-induced cell migration.ConclusionThese findings demonstrated that AVL9 contributed to CRC cell migration by regulating EGFR expression, suggesting a potential biomarker and treatment target for CRC.
Highlights
Despite advanced treatments could inhibit progression of colorectal carcinoma (CRC), the recurrence and metastasis remain challenging issues
AVL9 is upregulated in colorectal carcinoma To investigate the role of AVL9 in CRC, we analyzed AVL9 expression at mRNA level in colorectal carcinoma based on the cancer genome atlas (TCGA) database
The current study revealed that AVL9 mRNA expression was significantly increased in colorectal carcinoma tissue compared to corresponding non-cancer tissue based on TCGA database
Summary
Despite advanced treatments could inhibit progression of colorectal carcinoma (CRC), the recurrence and metastasis remain challenging issues. Accumulating evidences implicated that AVL9 played a vital role in human cancers, but it’s biological function and mechanism in CRC remain unclear. Colorectal carcinoma (CRC), ranking as one of the most common cancers among males and females, is an important threat to human health [1]. CRC is a multifactorial disease that can be caused by risk factors such as age, obesity, smoking habit, alcohol use and family history [3]. Intrusive procedures, such as colonoscopy, are the primary diagnostic means [4]. It’s urgent to provide a novel biomarker for CRC patients
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