Abstract
Nonsteroidal antiinflammatory drugs (NSAIDs) are the most often prescribed drugs throughout the world. They are divided into non-selective inhibitors for COX-1 and 2, which reduce the production of all PGs, constituents or not, and selective for COX-2, which inhibit only the deleterious PGs, which act on the inflammatory reaction. The hepatic function of Rattus norvegicus after the use of the nonselective NSAIDs ketoprofen and the selective NSAIDs valdecoxib, was studied. The doses administered to the animals were calculated according to the allometric scale. The serum values of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were measured, and the liver and kidney were also evaluated macroscopically and microscopically on different periods after the last administration of the drugs, according to the group to which the animal belonged. Among other observations, it can be stated that ketoprofen can cause death in rats, according to allometry, on the second day of drug administration, and that valdecoxib does not produce the noteworthy macroscopic and microscopicalterations in organs like the liver and kidney of Rattus norvegicus.
Highlights
Nonsteroidal antiinflammatory drugs (NSAIDs) are the most often prescribed drugs throughout the world. They are divided into non-selective inhibitors for COX-1 and 2, which reduce the production of all PGs, constituents or not, and selective for COX-2, which inhibit only the deleterious PGs, which act on the inflammatory reaction
Na avaliação microscópica do rim, independente do subgrupo, visualizou-se em nove animais (60%) degeneração e necrose tubular, que variou de multifocal discreta a acentuada
It can be stated that ketoprofen can cause death in rats, according to allometry, on the second day of drug administration, and that valdecoxib does not produce the noteworthy macroscopic and microscopicalterations in organs like the liver and kidney of Rattus norvegicus
Summary
Este estudo seguiu os princípios éticos do Colégio Brasileiro de Experimentação Animal (COBEA). O grupo K foi subdividido em K1, K2 e K3, sendo que cada um desses subgrupos foi composto por cinco animais que receberam cetoprofeno e mais um animal para cada subgrupo destinado à aplicação de placebo. O segundo grupo, denominado V, foi subdividido em V1, V2 e V3, sendo que cada um desses subgrupos ficou constituído por cinco animais cada para a administração do valdecoxib e mais um animal para cada subgrupo para a administração de placebo. Os animais receberam as doses de valdecoxib a cada dez horas, durante quatro dias. O mesmo aconteceu com os animais do grupo V, que receberam o tratamento com o valdecoxib em intervalos de 10/10 horas, durante quatro dias, baseando-se no modelo de peso representado por um homem com 70 kg. Optou-se também pela retirada do rim esquerdo para envio à análise histológica
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