Abstract
Binding sites for excitatory amino acids have been determined by autoradiographical procedures in the rat hippocampus and striatum during hippocampal kindling. The binding sites measured were the N-methyl- d-aspartate (NMDA)-sensitive sites for l-[ 3H]glutamate and [ 3H]MK-801 sites (transmitter recognition site and ion channel of the NMDA receptor, respectively), [ 3H]α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) sites (quisqualate receptor), [ 3H]kainate sites (kainate receptor) and NMDA-insensitive sites for l-[ 3H]glutamate. In general, little change was apparent in the hippocampus or striatum for any of these binding sites when assessed 48 h after attaining stages1/2, 3 or 5 of kindling. These results suggest that hippocampal kindling does not bring about a change in the excitatory amino acid receptor binding sites examined, and that the appearance of an NMDA receptor-mediated component to synaptic responses in the hippocampus produced by kindling 15, cannot be explained on this basis.
Published Version
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