Abstract
The present study uses in vitro autoradiography to localize 2-[ 125I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[ 125I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice.
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