Abstract
Abnormal autophagy is related to the pathogenesis and clinical symptoms of myelodysplastic syndrome (MDS). However, the effect of autophagy-related genes (ARGs) on the prognosis of MDS remains unclear. Here, we examined the expression profile of 108 patients with MDS from the GSE58831 dataset, and identified 22 genes that were significantly associated with overall survival. Among them, seven ARGs were screened and APIs were calculated for all samples based on the expression of the seven ARGs, and then, MDS patients were categorized into high- and low-risk groups based on the median APIs. The overall survival of patients with high-risk scores based on these seven ARGs was shorter than patients with low-risk scores in both the training cohort (P = 2.851e-06) and the validation cohort (P = 9.265e-03). Additionally, API showed an independent prognostic indicator for survival in the training samples [hazard ratio (HR) = 1.322, 95% confidence interval (CI): 1.158–1.51; P < 0.001] and the validation cohort (HR = 1.05, 95% CI: 1–1.1; P < 0.01). The area under the receiver operating characteristic curve (AUROC) of API and IPSS were 43.0137 and 66.0274 in the training cohorts and the AUC of the validation cohorts were 41.5361 and 72.0219. Our data indicate these seven ARGs can predict prognosis in patients with MDS and could guide individualized treatment.
Highlights
Myelodysplastic syndrome (MDS) is a malignant clonal hematopoietic stem cell disorder characterized by the proliferation of bone marrow primordial cells and a decrease in peripheral blood cells [1]
The other 55 patients were low-risk according to autophagy prognostic index (API), which containing 32 male and 23 female, and the age of 37 patients were above 60 years old, while 18 patients were below 60
The other 39 patients were low-risk according to API, which containing 19 male and 20 female, and the age of 28 patients were above 60 years old, while 11 patients were below 60
Summary
Myelodysplastic syndrome (MDS) is a malignant clonal hematopoietic stem cell disorder characterized by the proliferation of bone marrow primordial cells and a decrease in peripheral blood cells [1]. ARGs Prognostic Model of MDS in the bone marrow microenvironment [4,5,6,7,8] Targeting these processes that are involved in the pathogenesis of MDS may improve patient outcomes. Multiple gene mutations have been identified and considered as important substrates for the development of MDS, such as RNA splicing, histone manipulation, DNA methylation, transcription factors, kinase signaling, DNA repair, cohesin proteins, and other signal transduction elements. These findings have a great influence on the judgement of prognostic, the selection of therapies, and future treatment endeavors
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call