Abstract
Background Aging in cardiovascular regulatory system for the model of hypertensive subjects was still not fully understood. We investigated the impact of aging on autonomic cardiovascular response in hypertensive model. Method In awake spontaneously hypertensive rats (SHR), those ages between 60 to 70 weeks old, and control group were measured arterial pressure and pulse rate. For measurement the cardiovascular response, phenylephrine (PE) or sodium nitroprusside were infused intravenously in both groups of animals. Results In aged SHR, the pressor response to PE (2 to 10 μg/kg) were not significantly different to the response in control. However, baroreflex index were significantly decreased in aged animals. Although, the index of sympathetic and parasympathetic nerve activity estimated by wavelet transform analysis were not significantly different between two groups. In addition, the responses evoked by stimulating vasomotor neurons in brain were not different between two groups, neither. Conclusion In SHR, aging effect to the baro-sensitive mechanism but not effect to pressor response to vasoconstrictor or activation of central sympatho-vasomotor neurons, indicate the central sympathoexcitatory response were maintained in aged hypertensive subjects, which could be one of reason for induce cardiovascular events.
Published Version
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